Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19386328 | 0.80 | ATM (0.36) | HPGDALDH1A1MAPTTDP1ACHE | |
| SCHEMBL19288105 | 0.80 | PARP1 (0.47) | PARP1HDAC8HDAC6FAAHHPGD | |
| SCHEMBL16068459 | 0.79 | ALDH1A1 (0.41) | HDAC6HPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL15830185 | 0.73 | PARP1 (0.41) | PARP1HDAC8HDAC6FAAHHPGD | |
| SCHEMBL23260541 | 0.73 | PARP1 (0.47) | PARP1HDAC8HDAC6FAAHHPGD | |
| SCHEMBL20661355 | 0.70 | — | — | |
| SCHEMBL22548658 | 0.70 | PARP1 (0.41) | PARP1HDAC8HDAC6FAAHHPGD | |
| SCHEMBL23451297 | 0.70 | GABRP (0.44) | MEN1KMT2A | |
| SCHEMBL20934968 | 0.69 | MEN1 (0.37) | HDAC8HDAC6HPGDALDH1A1MAPT | |
| SCHEMBL24426635 | 0.69 | PARP1 (0.43) | PARP1HDAC8HDAC6FAAHHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10479790-B2 | COMT inhibiting methods and compositions | LIEBER INSTITUTE FOR BRAIN DEVELOPMENT (US) | 2019-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10479790-B2 | COMT inhibiting methods and compositions | COMT, SLC6A3, MAOA | PARP1 2858/4885HDAC8 2975/4885HDAC6 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.