Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 9/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.49 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | NCF1 | P14598 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10289221 | 0.88 | LMNA (0.51) | CHKALMNAMC4RKDM4ENPC1 | |
| SCHEMBL19291552 | 0.87 | HRH3 (0.62) | — | |
| SCHEMBL17409816 | 0.79 | HRH3 (0.59) | CHKALMNAMC4RKDM4ENPC1 | |
| SCHEMBL21565654 | 0.78 | CHKA (0.60) | CHKALMNATNIKMC4RCA2 | |
| SCHEMBL20443001 | 0.77 | ALDH1A1 (0.54) | KDM4ENPC1TP53RAB9A | |
| SCHEMBL21414371 | 0.77 | HRH3 (0.52) | CHKALMNAMC4RKDM4ENPC1 | |
| SCHEMBL306744 | 0.76 | LMNA (0.69) | CHKALMNAMC4RKDM4ENPC1 | |
| SCHEMBL12190331 | 0.76 | METAP2 (0.43) | NPC1TP53RAB9A | |
| SCHEMBL10460931 | 0.76 | METAP2 (0.43) | NPC1TP53RAB9A | |
| SCHEMBL17465327 | 0.76 | CHKA (0.87) | CHKALMNAMC4RKDM4ECA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558085-B1 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER | ATHENEX INC (US) | 2017-08-30 | — | — | EP | disclosed |