Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | VDR | P11473 | 1/20 | 0.58 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | POLA1 | P09884 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 1/20 | 0.49 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.49 |
| ▸ | NPC1L1 | Q9UHC9 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17379915 | 0.88 | VDR (0.56) | GPBAR1CYP2C9HIF1AVDRNR1H3 | |
| SCHEMBL19293413 | 0.85 | GPBAR1 (0.56) | GPBAR1CYP2C9HIF1AVDRNR1H3 | |
| SCHEMBL25334068 | 0.83 | VDR (0.51) | GPBAR1CYP2C9HIF1AVDRNR1H3 | |
| SCHEMBL25334071 | 0.83 | VDR (0.51) | GPBAR1CYP2C9HIF1AVDRNR1H3 | |
| SCHEMBL19293421 | 0.81 | GPBAR1 (0.52) | GPBAR1CYP2C9HIF1AVDRNR1H3 | |
| SCHEMBL18844009 | 0.81 | GPBAR1 (0.66) | GPBAR1CYP2C9HIF1AVDRNR1H3 | |
| SCHEMBL10074101 | 0.79 | GPBAR1 (0.60) | GPBAR1CYP2C9HIF1AVDRNR1H3 | |
| SCHEMBL14056665 | 0.78 | GPBAR1 (0.65) | GPBAR1CYP2C9HIF1AVDRNR1H3 | |
| SCHEMBL17317988 | 0.78 | GPBAR1 (0.65) | GPBAR1CYP2C9HIF1AVDRNR1H3 | |
| SCHEMBL23776945 | 0.78 | GPBAR1 (0.69) | GPBAR1CYP2C9HIF1AVDRNR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170247405-A1 | OXYSTEROLS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247405-A1 | OXYSTEROLS AND METHODS OF USE THEREOF | NR1H3, NR1H2, HSD17B7 | GPBAR1 116/4885CYP2C9 136/4885HIF1A 1624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.