Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476548 | 0.91 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL17446992 | 0.82 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL1376033 | 0.81 | GSK3A (0.63) | MAPTMEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL17016688 | 0.75 | MAPT (0.54) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL1752841 | 0.74 | ALPL (0.54) | MAPTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL22130300 | 0.74 | ALPL (0.53) | MAPTMEN1KMT2APDE3BPDE3A | |
| SCHEMBL17016671 | 0.74 | MAPT (0.59) | MAPTMEN1KMT2ASMN1; SMN2MAPK1 | |
| SCHEMBL11396912 | 0.74 | L3MBTL1 (0.58) | MAPTGAATP53CYP1A2GSK3B | |
| SCHEMBL1753098 | 0.74 | ALPL (0.53) | MAPTMEN1KMT2ATP53ALPL | |
| SCHEMBL29295442 | 0.74 | CA12 (0.56) | MAPTMAPK1CYP1A2CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170247335-A1 | FLUORINATED PYRIDAZIN-3-ONES FOR THE USE THEREOF IN THE TREATMENT OF LUNG DISEASES | INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247335-A1 | FLUORINATED PYRIDAZIN-3-ONES FOR THE USE THEREOF IN THE TREATMENT OF LUNG DISEASES | PEX3, NCOA3, NCAPD3 | PDE4A 2836/4885PDE4B 3398/4885PDE4C 3502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.