Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | AIP | O00170 | 1/20 | 0.35 |
| ▸ | SGTA | O43765 | 1/20 | 0.35 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246364 | 0.87 | PTK2 (0.49) | EPHB4MAPK10MAPK8MAPK9MAPT | |
| SCHEMBL26295499 | 0.86 | EPHB4 (0.39) | EPHB4MAPK10MAPK8MAPK9MAPT | |
| SCHEMBL14585671 | 0.83 | ADRA2A (0.36) | EPHB4MAPK10MAPK8MAPK9MAPT | |
| SCHEMBL15965535 | 0.82 | ANO1 (0.38) | EPHB4MAPK10MAPK8MAPK9MAPT | |
| SCHEMBL20014923 | 0.80 | MAPK1 (0.58) | MAPK10MAPK8MAPK9MAPTMAPK1 | |
| SCHEMBL560978 | 0.79 | IKBKB (0.35) | EPHB4MAPK8MAPTMAPK1IKBKB | |
| SCHEMBL12204339 | 0.79 | EPHB4 (0.36) | EPHB4MAPK10MAPK8MAPK9MAPT | |
| SCHEMBL24322190 | 0.79 | MELK (0.40) | EPHB4MAPK10MAPK8MAPK9MAPT | |
| SCHEMBL941528 | 0.78 | ALDH1A1 (0.47) | EPHB4MAPK10MAPK8MAPK9MAPT | |
| SCHEMBL7002116 | 0.74 | FLT3 (0.46) | MAPTMAPK1ALDH1A1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110152234-A1 | Novel Compounds | ASTRAZENECA AB (SE) | 2011-06-23 | — | — | US | disclosed |
| US-7956084-B2 | Phenyl thiophene carboxamide compounds as inhibitors of the enzyme IKK-2 | ASTRAZENECA AB (SE) | 2011-06-07 | — | — | US | disclosed |
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | disclosed |
| US-20070015819-A1 | Novel compounds | ASTRAZENECA AB, A SWEDEN CORPORATION | 2007-01-18 | — | — | US | disclosed |
| US-7125896-B2 | Thiophene carboxamide compounds as inhibitors of enzyme IKK-2 | ASTRAZENECA AB (SE) | 2006-10-24 | — | — | US | disclosed |
| US-20040242573-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2004-12-02 | — | — | US | disclosed |
| EP-1421074-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003010158-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015819-A1 | Novel compounds | CNR1, ABCG2, CNR2 | EPHB4 2733/4885MAPK10 3958/4885MAPK8 4539/4885 |
| US-20040242573-A1 | Novel compounds | SULT1E1, TPMT, UGT1A1 | EPHB4 3230/4885MAPK10 3787/4885MAPK8 4468/4885 |
| US-20110152234-A1 | Novel Compounds | CNR1, ABCG2, CNR2 | EPHB4 2733/4885MAPK10 3958/4885MAPK8 4539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.