Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 12/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14959919 | 0.95 | KIF11 (0.58) | KIF11MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL26375411 | 0.91 | KIF11 (0.53) | KIF11MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL12937177 | 0.88 | KIF11 (0.67) | KIF11PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL16906613 | 0.88 | KIF11 (0.47) | KIF11MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL24211025 | 0.86 | RXRA (0.50) | KIF11MAPTCNR2 | |
| SCHEMBL24211077 | 0.86 | RXRA (0.50) | KIF11MAPTCNR2 | |
| SCHEMBL20022112 | 0.86 | KIF11 (0.55) | KIF11 | |
| SCHEMBL25944996 | 0.86 | KIF11 (0.45) | KIF11MAPTPSEN1PSEN2APH1B | |
| SCHEMBL24518592 | 0.84 | RXRA (0.48) | KIF11MAPTCNR2 | |
| SCHEMBL20022126 | 0.84 | KIF11 (0.57) | KIF11MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017147335-A1 | BACTERIAL EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-08-31 | — | — | WO | disclosed |