Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 6/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19284354 | 0.83 | LMNA (0.45) | PADI4RAB9APTGER4AVPR1BKDM4E | |
| SCHEMBL27757298 | 0.78 | NOTUM (0.43) | KDM2BMAPTNOTUMPTGER4MTOR | |
| SCHEMBL19301627 | 0.77 | KDM4E (0.43) | PADI4NPSR1MEN1MAPTRAB9A | |
| SCHEMBL19284316 | 0.75 | ALDH1A1 (0.38) | PADI4KDM2BNPSR1MAPTKDM4E | |
| SCHEMBL19301734 | 0.73 | KDM4E (0.40) | PADI4NPSR1MEN1MAPTRAB9A | |
| SCHEMBL5353171 | 0.71 | ADORA2A (0.43) | MEN1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL19284323 | 0.70 | PADI4 (0.39) | PADI4 | |
| SCHEMBL8669626 | 0.70 | MAP4K4 (0.48) | KMT2ATGFBR1 | |
| SCHEMBL19284370 | 0.69 | CYP1A2 (0.48) | NOTUMPTGER4KDM4EALDH1A1HSD17B10 | |
| SCHEMBL19301633 | 0.67 | TDP1 (0.46) | PADI4NPSR1MEN1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017147102-A1 | HETEROARYL INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2017-08-31 | — | — | WO | disclosed |