Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2692818 | 0.91 | KMT2A (0.61) | ALOX5HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL11699696 | 0.90 | NPC1 (0.55) | ALOX5HDAC1HDAC2MAPK1LMNA | |
| SCHEMBL19289874 | 0.86 | ALOX5 (0.63) | ALOX5HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4075176 | 0.84 | LMNA (0.75) | ALOX5MAPK1LMNANPC1ALOX15 | |
| SCHEMBL8493143 | 0.83 | ALOX5 (0.69) | ALOX5HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL4558654 | 0.83 | MLYCD (0.58) | ALOX5HDAC3HDAC1HDAC2HDAC8 | |
| Hydrochloric Acid SCHEMBL27410606 | 0.81 | ALOX5 (0.67) | ALOX5HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL14382148 | 0.81 | LMNA (0.71) | ALOX5HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL4075172 | 0.80 | LMNA (0.69) | ALOX5HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL25516970 | 0.79 | ALOX5 (0.54) | ALOX5MAPK1LMNANPC1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170247382-A1 | SMALL MOLECULES TARGETING ANDROGEN RECEPTOR NUCLEAR LOCALIZATION AND/OR LEVEL IN PROSTATE CANCER | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247382-A1 | SMALL MOLECULES TARGETING ANDROGEN RECEPTOR NUCLEAR LOCALIZATION AND/OR LEVEL IN PROSTATE CANCER | AR, NCOR1, NCOA1 | ALOX5 4097/4885HDAC3 88/4885HDAC1 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.