Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8336829 | 0.87 | TDP1 (0.41) | PTPN1TDP1ALOX15ALDH1A1USP2 | |
| SCHEMBL21143359 | 0.85 | ALDH1A1 (0.33) | PTPN1TDP1ALDH1A1CYP3A4MAPT | |
| SCHEMBL22689608 | 0.84 | TDP1 (0.45) | PTPN1TDP1ALOX15ALDH1A1USP2 | |
| SCHEMBL995233 | 0.83 | PTPN1 (0.56) | PTPN1TDP1ALOX15ALDH1A1USP2 | |
| SCHEMBL20630298 | 0.83 | ALDH1A1 (0.50) | PTPN1TDP1ALOX15ALDH1A1USP2 | |
| SCHEMBL28289298 | 0.83 | BLM (0.35) | PTPN1MAPTBLM | |
| SCHEMBL11821362 | 0.83 | ALDH1A1 (0.50) | PTPN1TDP1ALOX15ALDH1A1CYP3A4 | |
| SCHEMBL21143369 | 0.82 | MGAM (0.38) | TDP1CYP3A4MAPTLMNAMEN1 | |
| SCHEMBL9848383 | 0.82 | PTPN1 (0.39) | PTPN1TDP1ALOX15ALDH1A1USP2 | |
| SCHEMBL21143382 | 0.82 | MAPT (0.42) | PTPN1TDP1ALDH1A1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017147410-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2017-08-31 | — | — | WO | disclosed |