Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | ESRRG | P62508 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19303136 | 0.79 | EPHX2 (0.63) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10099587 | 0.79 | EPHX2 (0.63) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27467294 | 0.78 | EPHX2 (0.61) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL496789 | 0.77 | SMN1; SMN2 (0.81) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27389698 | 0.74 | EPHX2 (0.65) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL27790062 | 0.74 | EPHX2 (0.65) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8851563 | 0.74 | EPHX2 (0.65) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL30914520 | 0.74 | EPHX2 (0.69) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL8056354 | 0.74 | GAA (0.57) | EPHX2NPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL10722901 | 0.73 | EPHX2 (0.73) | EPHX2NPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130315-A | SUBSTRATES IN WHICH THE SCISSILE AMIDE BOND HAS BEEN REPLACED BY AN ACTIVATED ELECTROPHILIC KETONE MOIETY; ANTIINFLAMMATORY AGENTS; ANTIPROLIFERATIVE/ANTICARCINOGENIC/ANTIARTHRITIC AGENTS; TREATMENT OF AUTOIMMUNE DISEASES | MERRELL PHARMACEUTICALS INC. (US) | 2000-10-10 | — | — | US | disclosed |
| US-5849866-A | Peptidase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1998-12-15 | — | — | US | disclosed |
| EP-0195212-B1 | Novel peptidase inhibitors | MERRELL DOW PHARMA (US) | 1993-11-24 | — | — | EP | disclosed |
| EP-0195212-A2 | Novel peptidase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-09-24 | — | — | EP | disclosed |