Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.53 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.53 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.53 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.53 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.46 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839934 | 1.00 | CA2 (0.53) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL7552288 | 1.00 | CA2 (0.53) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL3785993 | 0.98 | GRIK1 (0.54) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL7550232 | 0.98 | GRIK1 (0.54) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL3864872 | 0.98 | GRIK1 (0.54) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL7552503 | 0.98 | GRIK1 (0.54) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL3857718 | 0.98 | GRIK1 (0.54) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL7551496 | 0.94 | CA2 (0.61) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL8847217 | 0.86 | GRIK1 (0.42) | CA2MAPK1GRIK1GRIK2SLC1A2 | |
| SCHEMBL7557794 | 0.86 | CHRM1 (0.62) | CA2MAPK1GRIK1GRIK2SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240341301-A1 | ITACONATE AND DERIVATIVES THEREOF FOR THE PROTECTION OF CELLS, TISSUES, AND ORGANS | UNIV MICHIGAN REGENTS (US) | 2024-10-17 | — | — | US | disclosed |
| US-20230241076-A1 | HISTONE-ACETYLATION-MODULATING AGENTS FOR THE TREATMENT AND PREVENTION OF ORGAN INJURY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-08-03 | — | — | US | disclosed |
| US-20230241076-A1 | HISTONE-ACETYLATION-MODULATING AGENTS FOR THE TREATMENT AND PREVENTION OF ORGAN INJURY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-08-03 | — | — | US | disclosed |
| US-20230069590-A1 | CONCENTRATED SODIUM VALPROATE FOR RAPID DELIVERY | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2023-03-02 | — | — | US | disclosed |
| US-20230058189-A1 | QUINOLIN-4-ONE AND 4(1H)-CINNOLINONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. (US) | 2023-02-23 | — | — | US | disclosed |
| CN-114340611-A | Combination of CHIR99021 and valproic acid for the treatment of hearing loss | 频率医疗公司 | 2022-04-12 | — | — | CN | disclosed |
| US-11260130-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV | Frequency Therapeutics, Inc. (US) | 2022-03-01 | — | — | US | disclosed |
| EP-3952854-A1 | COMBINATION OF CHIR99021 AND VALPROIC ACID FOR TREATING HEARING LOSS | Frequency Therapeutics, Inc. (US) | 2022-02-16 | — | — | EP | disclosed |
| US-20210300948-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | Frequency Therapeutics, Inc. | 2021-09-30 | — | — | US | disclosed |
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2021-07-20 | — | — | US | disclosed |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | Frequency Therapeutics, Inc. (US) | 2019-08-20 | — | — | US | disclosed |
| US-20190201398-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING A GSK3 INHIBITOR: I | Frequency Therapeutics, Inc. | 2019-07-04 | — | — | US | disclosed |
| US-20190093079-A1 | METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK-3-ALPHA INHIBITORS | Frequency Therapeutics, Inc. | 2019-03-28 | — | — | US | disclosed |
| US-10201540-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I | Frequency Therapeutics, Inc. (US) | 2019-02-12 | — | — | US | disclosed |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | Frequency Therapeutics, Inc. | 2018-08-02 | — | — | US | disclosed |
| US-10016507-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: III | Frequency Therapeutics, Inc. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170252329-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: II | Frequency Therapeutics, Inc. | 2017-09-07 | — | — | US | disclosed |
| US-20170252449-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: III | Frequency Therapeutics, Inc. | 2017-09-07 | — | — | US | disclosed |
| US-20170252450-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING A GSK3 INHIBITOR: IV | Frequency Therapeutics, Inc. | 2017-09-07 | — | — | US | disclosed |
| US-20170252340-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: I | Frequency Therapeutics, Inc. | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (17 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230241076-A1 | HISTONE-ACETYLATION-MODULATING AGENTS FOR THE TREATMENT AND PREVENTION OF ORGAN INJURY | HDAC2, HDAC1, CREBBP | CA2 1912/4885MAPK1 1913/4885GRIK1 1140/4885 |
| US-20170252450-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING A GSK3 INHIBITOR: IV | GSK3B, GSK3A, GSKIP | CA2 1649/4885MAPK1 443/4885GRIK1 2770/4885 |
| US-10016507-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: III | GSK3B, GSK3A, GSKIP | CA2 1523/4885MAPK1 316/4885GRIK1 2547/4885 |
| US-20170252329-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: II | GSK3B, GSK3A, GSKIP | CA2 1205/4885MAPK1 341/4885GRIK1 2531/4885 |
| US-20230069590-A1 | CONCENTRATED SODIUM VALPROATE FOR RAPID DELIVERY | CACNA1G, CACNA1C, CACNA1H | CA2 292/4885MAPK1 4043/4885GRIK1 46/4885 |
| US-20210300948-A1 | 1H-PYRROLE-2,5-DIONE COMPOUNDS AND METHODS OF USING THEM TO INDUCE SELF-RENEWAL OF STEM/PROGENITOR SUPPORTING CELLS | MCL1, PROX1, MKI67 | CA2 4491/4885MAPK1 3170/4885GRIK1 3223/4885 |
| US-10201540-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I | GSK3B, GSK3A, GSKIP | CA2 1521/4885MAPK1 244/4885GRIK1 2240/4885 |
| US-20180214458-A1 | 1,5-DIHYDRO-2H-PYRROL-2-ONE COMPOUNDS AND METHODS OF USING SAME | DCX, MKI67, MCL1 | CA2 4173/4885MAPK1 2194/4885GRIK1 2809/4885 |
| US-20190093079-A1 | METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK-3-ALPHA INHIBITORS | GSK3A, GSK3B, NOTCH3 | CA2 668/4885MAPK1 1778/4885GRIK1 595/4885 |
| US-20170252449-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: III | GSK3B, GSK3A, GSKIP | CA2 1523/4885MAPK1 316/4885GRIK1 2547/4885 |
| US-20170252340-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK3 INHIBITORS: I | GSK3B, GSK3A, GSKIP | CA2 1521/4885MAPK1 244/4885GRIK1 2240/4885 |
| US-10383881-B2 | 1,5-dihydro-2H-pyrrol-2-one compounds and methods of using same | DCX, MKI67, MCL1 | CA2 4173/4885MAPK1 2194/4885GRIK1 2809/4885 |
| US-20230058189-A1 | QUINOLIN-4-ONE AND 4(1H)-CINNOLINONE COMPOUNDS AND METHODS OF USING SAME | DCX, NES, MCL1 | CA2 4078/4885MAPK1 1437/4885GRIK1 1886/4885 |
| US-20190201398-A1 | SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING A GSK3 INHIBITOR: I | GSK3B, GSK3A, GSKIP | CA2 1639/4885MAPK1 313/4885GRIK1 2378/4885 |
| US-11066419-B2 | 1H-pyrrole-2,5-dione compounds and methods of using same | MKI67, PROX1, DCX | CA2 4161/4885MAPK1 2543/4885GRIK1 3429/4885 |
| US-20240341301-A1 | ITACONATE AND DERIVATIVES THEREOF FOR THE PROTECTION OF CELLS, TISSUES, AND ORGANS | TNNI3, ALDH2, ALDH5A1 | CA2 2897/4885MAPK1 3714/4885GRIK1 3458/4885 |
| US-11260130-B2 | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV | GSK3B, GSK3A, GSKIP | CA2 1649/4885MAPK1 443/4885GRIK1 2770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.