Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19308218 | 0.82 | LMNA (0.44) | LMNAHTTSMN1; SMN2ALDH1A1APOBEC3A | |
| SCHEMBL25258567 | 0.82 | LMNA (0.44) | LMNAHTTSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL19308216 | 0.79 | CHRNB2 (0.49) | LMNAHTTSMN1; SMN2ALDH1A1APOBEC3A | |
| SCHEMBL10461059 | 0.78 | SLC18A3 (0.64) | LMNAHTTMAPTSLC18A3SIGMAR1 | |
| SCHEMBL23052014 | 0.77 | SMN1; SMN2 (0.60) | LMNAHTTSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18318428 | 0.76 | NAMPT (0.42) | LMNATSHRHTR2C | |
| SCHEMBL12017803 | 0.76 | HTR6 (0.46) | LMNAALDH1A1KMT2AMEN1TSHR | |
| SCHEMBL2798239 | 0.76 | MAPT (0.50) | LMNAALDH1A1MAPTMAPK1TSHR | |
| SCHEMBL5212828 | 0.76 | CYP11B1 (0.49) | LMNATSHRHTR2CHTR6 | |
| SCHEMBL1865965 | 0.76 | HTR6 (0.44) | LMNAALDH1A1TSHRHTR6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9752149-B2 | Matriptase inhibitors and uses thereof against orthomyxoviridae infections | SOCPRA Sciences Sante et Humaines S.E.C. (CA) | 2017-09-05 | — | — | US | disclosed |