Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | MMP12 | P39900 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | CMA1 | P23946 | 5/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16704191 | 0.86 | HPGD (0.56) | HPGDCMA1KDM4EALDH1A1 | |
| SCHEMBL16703464 | 0.78 | RAD52 (0.45) | CCNCCDK8MMP12MMP13CMA1 | |
| SCHEMBL10192199 | 0.77 | IDH1 (0.43) | CCNCCDK8MMP12MMP13CMA1 | |
| SCHEMBL850221 | 0.77 | TSHR (0.50) | HPGDCCNCCDK8MMP12MMP13 | |
| SCHEMBL11741584 | 0.77 | CCNC (0.40) | CCNCCDK8MMP12MMP13CMA1 | |
| SCHEMBL15499081 | 0.75 | PKM (0.48) | HPGDCCNCCDK8CMA1KDM4E | |
| SCHEMBL17151142 | 0.74 | PIK3CA (0.47) | CCNCCDK8CMA1ALDH1A1 | |
| SCHEMBL8256507 | 0.74 | SCN9A (0.43) | CCNCCDK8MMP12MMP13CMA1 | |
| SCHEMBL19308367 | 0.73 | CMA1 (0.44) | HPGDCMA1ALDH1A1 | |
| SCHEMBL19308381 | 0.72 | CRHR1 (0.37) | CMA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9751843-B2 | Substituted uracils and use thereof | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-05 | — | — | US | disclosed |