Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL16493757 | 0.89 | L3MBTL1 (0.47) | L3MBTL1TSHRGPBAR1ALDH1A1KDM4E | |
| SCHEMBL1930210 | 0.85 | L3MBTL1 (0.51) | L3MBTL1TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1929695 | 0.85 | L3MBTL1 (0.53) | L3MBTL1TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1929911 | 0.82 | MAPK1 (0.50) | L3MBTL1TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1929145 | 0.81 | L3MBTL1 (0.49) | L3MBTL1TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1930307 | 0.80 | L3MBTL1 (0.56) | L3MBTL1TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1928761 | 0.79 | L3MBTL1 (0.57) | L3MBTL1TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3862704 | 0.78 | L3MBTL1 (0.51) | L3MBTL1TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1930375 | 0.77 | ALDH1A1 (0.49) | L3MBTL1TSHRALDH1A1KDM4EHSD17B10 | |
| SCHEMBL1930432 | 0.77 | L3MBTL1 (0.58) | L3MBTL1TSHRALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956074-B2 | Aryl-isoxazolo-4-yl-oxadiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-07 | — | — | US | disclosed |