Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1930375 | 0.88 | ALDH1A1 (0.49) | GABRA5TSHRHPGDHSD17B10POLB | |
| SCHEMBL1930363 | 0.88 | NPC1 (0.50) | MAPK1TSHRHPGDHSD17B10POLB | |
| SCHEMBL3864355 | 0.86 | MAPK1 (0.45) | MAPK1GABRA5TSHRHPGDHSD17B10 | |
| SCHEMBL3862847 | 0.83 | L3MBTL1 (0.53) | MAPK1TSHRHPGDHSD17B10L3MBTL1 | |
| SCHEMBL1930206 | 0.83 | L3MBTL1 (0.48) | MAPK1GABRA5TSHRHPGDHSD17B10 | |
| SCHEMBL1929051 | 0.83 | L3MBTL1 (0.51) | MAPK1TSHRHPGDHSD17B10POLB | |
| SCHEMBL1930896 | 0.82 | L3MBTL1 (0.44) | TSHRHPGDHSD17B10POLBL3MBTL1 | |
| SCHEMBL1931057 | 0.82 | L3MBTL1 (0.45) | MAPK1TSHRHPGDHSD17B10L3MBTL1 | |
| SCHEMBL1929849 | 0.82 | L3MBTL1 (0.46) | MAPK1GABRA5TSHRHPGDHSD17B10 | |
| SCHEMBL1930420 | 0.81 | L3MBTL1 (0.49) | MAPK1TSHRHSD17B10L3MBTL1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956074-B2 | Aryl-isoxazolo-4-yl-oxadiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-07 | — | — | US | disclosed |