Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21886738 | 0.91 | USP2 (0.49) | USP2SMN1; SMN2RECQLEIF2AK4HPGD | |
| SCHEMBL31309984 | 0.89 | SMN1; SMN2 (0.54) | USP2SMN1; SMN2RECQLEIF2AK4HPGD | |
| SCHEMBL19320633 | 0.88 | USP2 (0.50) | USP2SMN1; SMN2RECQLEIF2AK4HPGD | |
| SCHEMBL29579532 | 0.88 | USP2 (0.56) | USP2SMN1; SMN2RECQLEIF2AK4HPGD | |
| SCHEMBL25306177 | 0.86 | SMN1; SMN2 (0.54) | USP2SMN1; SMN2RECQLEIF2AK4HPGD | |
| SCHEMBL31197156 | 0.85 | USP2 (0.53) | USP2SMN1; SMN2RECQLEIF2AK4HPGD | |
| SCHEMBL714947 | 0.85 | USP2 (0.53) | USP2SMN1; SMN2RECQLEIF2AK4HPGD | |
| SCHEMBL25713283 | 0.84 | USP2 (0.49) | USP2SMN1; SMN2RECQLEIF2AK4HPGD | |
| SCHEMBL25713743 | 0.84 | USP2 (0.49) | USP2SMN1; SMN2RECQLEIF2AK4HPGD | |
| SCHEMBL21254445 | 0.84 | SMN1; SMN2 (0.59) | USP2SMN1; SMN2RECQLEIF2AK4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2022-04-28 | — | — | US | disclosed |
| US-20170253615-A1 | Spirocyclic derivatives | SHIRE INTERNATIONAL GMBH (CH) | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253615-A1 | Spirocyclic derivatives | SLC6A3, SLC10A1, ABCB11 | USP2 4814/4885SMN1; SMN2 3011/4885RECQL 387/4885 |
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | USP2 3838/4885SMN1; SMN2 1943/4885RECQL 130/4885 |
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | USP2 3838/4885SMN1; SMN2 1943/4885RECQL 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.