Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17609116 | 1.00 | PTGS2 (0.65) | PTGS2KCNH2MAOBMAOAAPP | |
| SCHEMBL1728679 | 0.91 | KCNH2 (0.65) | KCNH2HRH3MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL17609051 | 0.87 | NFE2L2 (0.63) | PTGS2MAOBMAOAAPPHRH3 | |
| SCHEMBL19327344 | 0.87 | NFE2L2 (0.63) | PTGS2MAOBMAOAAPPHRH3 | |
| SCHEMBL9827026 | 0.85 | PTGS2 (0.77) | PTGS2MAOBLMNAMAPTALDH1A1 | |
| SCHEMBL9827029 | 0.85 | PTGS2 (0.77) | PTGS2MAOBLMNAMAPTALDH1A1 | |
| SCHEMBL1962562 | 0.84 | KCNH2 (0.68) | PTGS2KCNH2HRH3MAPTCHRNB2 | |
| SCHEMBL8491464 | 0.83 | ALDH1A1 (0.52) | PTGS2KCNH2MAOBHRH3LMNA | |
| SCHEMBL8491471 | 0.83 | ALDH1A1 (0.52) | PTGS2KCNH2MAOBHRH3LMNA | |
| SCHEMBL19327365 | 0.82 | BCHE (0.53) | PTGS2MAOBMAOAAPPHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170260126-A1 | SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION | UNIV OXFORD INNOVATION LTD (GB) | 2017-09-14 | — | — | US | claimed |
| US-20170260126-A1 | SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION | UNIV OXFORD INNOVATION LTD (GB) | 2017-09-14 | — | — | US | disclosed |
| US-20170260126-A1 | SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION | UNIV OXFORD INNOVATION LTD (GB) | 2017-09-14 | — | — | US | disclosed |
| US-20170260126-A1 | SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION | UNIV OXFORD INNOVATION LTD (GB) | 2017-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170260126-A1 | SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION | LDLR, NR1H2, SREBF1 | PTGS2 798/4885KCNH2 4178/4885MAOB 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.