Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | F9 | P00740 | 2/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | TACR2 | P21452 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19331205 | 0.83 | SLC6A9 (0.37) | SLC6A9GRIN1F9WDR5MAPT | |
| SCHEMBL19331168 | 0.80 | POLB (0.38) | F9WDR5CREBBPPHGDHTACR2 | |
| Hydrochloric Acid SCHEMBL19331242 | 0.80 | KDM4E (0.37) | DYRK1ADYRK1BAKT1LMNAMAPT | |
| SCHEMBL19330891 | 0.80 | SLC6A9 (0.34) | SLC6A9F9WDR5MAPTSMN1; SMN2 | |
| SCHEMBL20768402 | 0.76 | PHGDH (0.59) | SLC6A9F9PHGDH | |
| SCHEMBL19331120 | 0.74 | PHGDH (0.47) | PHGDHEGFR | |
| SCHEMBL19331329 | 0.73 | PHGDH (0.42) | GRIN1PHGDHMCL1EGFR | |
| SCHEMBL19331006 | 0.71 | ALDH1A1 (0.37) | LMNAMAPTSMN1; SMN2 | |
| SCHEMBL19330953 | 0.70 | PHGDH (0.41) | PHGDHEGFRAKT1 | |
| SCHEMBL19331111 | 0.70 | PHGDH (0.37) | PHGDHEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426243-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics Inc. (US) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017156165-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |