⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475102 | 0.80 | ALDH1A1 (0.55) | — | |
| SCHEMBL243344 | 0.78 | — | — | |
| SCHEMBL157088 | 0.76 | — | — | |
| SCHEMBL3247663 | 0.76 | — | — | |
| SCHEMBL11392166 | 0.76 | — | — | |
| SCHEMBL10716657 | 0.73 | — | — | |
| SCHEMBL543681 | 0.71 | — | — | |
| SCHEMBL11377122 | 0.71 | ALDH1A1 (0.47) | — | |
| SCHEMBL2859096 | 0.70 | LMNA (0.73) | — | |
| SCHEMBL6986795 | 0.70 | MAPT (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 111 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102718731-B | 4 /5-methyl-1, 2, 3-thiadiazole formic acid derivative and preparation method thereof | TIANJIN UNIVERSITY OF COMMERCE (CN) | 2014-10-01 | — | — | CN | claimed |
| CN-102432563-B | Dihydrazide compounds containing 4-methyl-1,2,3-thiadiazole group, and preparation method and application of dihydrazide compounds | UNIV NANKAI | 2013-12-04 | — | — | CN | claimed |
| CN-102718731-A | 4 /5-methyl-1, 2, 3-thiadiazole formic acid derivative and preparation method thereof | UNIV TIANJIN COMMERCE | 2012-10-10 | — | — | CN | claimed |
| CN-102633747-A | 5-methyl-1, 2, 3-thiadiazole bishydrazide derivatives as well as preparation method and application thereof | UNIV NANKAI | 2012-08-15 | — | — | CN | claimed |
| CN-102633746-A | Di-hydrazide derivatives containing 5-methyl-1, 2, 3-thiadizole and preparation method and application of di-hydrazide derivatives containing 5-methyl-1, 2, 3-thiadizole | UNIV NANKAI | 2012-08-15 | — | — | CN | claimed |
| CN-102432563-A | Dihydrazide compounds containing 4-methyl-1,2,3-thiadiazole group, and preparation method and application of dihydrazide compounds | UNIV NANKAI | 2012-05-02 | — | — | CN | claimed |
| CN-101891708-B | Bishydrazide compound containing 4-methyl-1, 2, 3-thiadiazole group and preparation method and application thereof | UNIV NANKAI | 2012-02-08 | — | — | CN | claimed |
| CN-102180871-A | 4-methyl-1,2,3-thiadiazole urea derivatives and preparation method and application thereof | UNIV NANKAI | 2011-09-14 | — | — | CN | claimed |
| CN-101891708-A | Bishydrazide compound containing 4-methyl-1, 2, 3-thiadiazole group and preparation method and application thereof | UNIV NANKAI | 2010-11-24 | — | — | CN | claimed |
| CN-101066972-B | [1,2,3]-thiobizole derivative and its synthesis process and use | UNIV NANKAI | 2010-06-02 | — | — | CN | claimed |
| CN-101591308-A | A kind ofly contain 1,2, bishydrazide derivative of 3-thiadiazoles active group and its production and use | UNIV NANKAI (CN) | 2009-12-02 | — | — | CN | claimed |
| CN-101544633-A | Synthesis technology for N-(5-methyl-1,3-thiazole-2-yl)-4-methyl-1,2,3-thiadiazole-5-methanamide | UNIV NANKAI | 2009-09-30 | — | — | CN | claimed |
| CN-100488963-C | New thiobizole formanide derivative and its synthesis process and bioactivity | UNIV NANKAI (CN) | 2009-05-20 | — | — | CN | claimed |
| CN-101343269-A | 1,2,3-thiadiazoles derivants, synthesis and use thereof | UNIV NANKAI (CN) | 2009-01-14 | — | — | CN | claimed |
| CN-100420686-C | [1,2,3] thiadiazole derivative and synthesis method and application thereof | UNIV NANKAI (CN) | 2008-09-24 | — | — | CN | claimed |
| CN-101066972-A | [1,2,3]-thiobizole derivative and its synthesis process and use | UNIV NANKAI (CN) | 2007-11-07 | — | — | CN | claimed |
| CN-101020687-A | New thiobizole formanide derivative and its synthesis process and bioactivity | UNIV NANKAI (CN) | 2007-08-22 | — | — | CN | claimed |
| CN-1810808-A | Novel [1,2,3] thiadiazole derivative and synthesis method and application thereof | UNIV NANKAI (CN) | 2006-08-02 | — | — | CN | claimed |
| CN-109928967-B | Cyclized berberine derivative and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2020-09-04 | — | — | CN | disclosed |
| US-3946031-A | FUNGICIDES | SYNTEX INC. (US) | 1976-03-23 | — | — | US | disclosed |