Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.80 |
| ▸ | MLNR | O43193 | 1/20 | 0.80 |
| ▸ | KDM1A | O60341 | 1/20 | 0.80 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.80 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.80 |
| ▸ | INSR | P06213 | 1/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.80 |
| ▸ | DRD2 | P14416 | 1/20 | 0.80 |
| ▸ | NQO2 | P16083 | 1/20 | 0.80 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.80 |
| ▸ | DRD1 | P21728 | 1/20 | 0.80 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.80 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.80 |
| ▸ | HTR2A | P28223 | 1/20 | 0.80 |
| ▸ | HTR2C | P28335 | 1/20 | 0.80 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.80 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Befotertinib SCHEMBL29774263 | 1.00 | EGFR (0.86) | EGFRKCNH2MLNRKDM1AABCB11 | |
| Befotertinib SCHEMBL30595515 | 1.00 | EGFR (0.86) | EGFRKCNH2MLNRKDM1AABCB11 | |
| Befotertinib SCHEMBL30354045 | 0.97 | EGFR (0.82) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL19337200 | 0.95 | EGFR (0.84) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL17553693 | 0.93 | EGFR (0.91) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL17683310 | 0.93 | EGFR (1.00) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL26554675 | 0.92 | EGFR (0.73) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL22968448 | 0.92 | EGFR (0.90) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL28412579 | 0.92 | EGFR (0.91) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL28409356 | 0.92 | EGFR (0.91) | EGFRKCNH2MLNRKDM1AABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230331703-A1 | EGFR INHIBITORS | InventisBio Co., Ltd. (CN) | 2023-10-19 | — | — | US | claimed |
| US-12227491-B2 | EGFR inhibitors | InventisBio Co., Ltd. (CN) | 2025-02-18 | — | — | US | disclosed |
| US-20240208967-A1 | Pyrimidine or Pyridine Compounds, Preparation Method Therefor and Pharmaceutical Uses Thereof | INVENTISBIO CO LTD (CN) | 2024-06-27 | — | — | US | disclosed |
| US-20230331703-A1 | EGFR INHIBITORS | InventisBio Co., Ltd. (CN) | 2023-10-19 | — | — | US | disclosed |
| US-20230331703-A1 | EGFR INHIBITORS | InventisBio Co., Ltd. (CN) | 2023-10-19 | — | — | US | disclosed |
| US-20230331703-A1 | EGFR INHIBITORS | InventisBio Co., Ltd. (CN) | 2023-10-19 | — | — | US | disclosed |
| US-20230331703-A1 | EGFR INHIBITORS | InventisBio Co., Ltd. (CN) | 2023-10-19 | — | — | US | disclosed |
| US-11639344-B2 | EGFR inhibitors | InventisBio Co., Ltd. (CN) | 2023-05-02 | — | — | US | disclosed |
| US-11639344-B2 | EGFR inhibitors | InventisBio Co., Ltd. (CN) | 2023-05-02 | — | — | US | disclosed |
| US-11639344-B2 | EGFR inhibitors | InventisBio Co., Ltd. (CN) | 2023-05-02 | — | — | US | disclosed |
| US-20210040068-A1 | EGFR INHIBITORS | InventisBio Co., Ltd. (CN) | 2021-02-11 | — | — | US | disclosed |
| US-20210040068-A1 | EGFR INHIBITORS | InventisBio Co., Ltd. (CN) | 2021-02-11 | — | — | US | disclosed |
| WO-2020228807-A1 | SALTS OF A CLASS OF PYRIMIDINE COMPOUNDS, POLYMORPHS, AND PHARMACEUTICAL COMPOSITIONS THEREOF, PREAPRATION METHODS THEREFOR AND USES THEREOF | 益方生物科技（上海）有限公司 | 2020-11-19 | — | — | WO | disclosed |
| WO-2019218987-A1 | EGFR INHIBITORS | INVENTISBIO SHANGHAI LTD. (CN) | 2019-11-21 | — | — | WO | disclosed |
| US-10376512-B1 | Crystal of aniline pyrimidine compound of trifluoroethyl substituted indole and salt thereof | CHIA TAI TIANQING PHARMAEUTICAL GROUP CO., LTD. (CN) | 2019-08-13 | — | — | US | disclosed |
| US-20190152969-A1 | PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | INVENTISBIO SHANGHAI LTD. (CN) | 2019-05-23 | — | — | US | disclosed |
| US-10179784-B2 | Pyrimidine or pyridine compounds, preparation method therefor and pharmaceutical uses thereof | INVENTISBIO SHANGHAI LTD. (CN) | 2019-01-15 | — | — | US | disclosed |
| US-20170355696-A1 | PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | InventisBio Co., Ltd. (CN) | 2017-12-14 | — | — | US | disclosed |
| US-20170355696-A1 | PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | InventisBio Co., Ltd. (CN) | 2017-12-14 | — | — | US | disclosed |
| EP-3216786-A1 | PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | Shanghai Shaletech Technology Co., Ltd. (CN) | 2017-09-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152969-A1 | PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | EGFR, WEE1, DPYD | EGFR 1/4885KCNH2 3939/4885MLNR 1080/4885 |
| US-20240208967-A1 | Pyrimidine or Pyridine Compounds, Preparation Method Therefor and Pharmaceutical Uses Thereof | EGFR, WEE1, DPYD | EGFR 1/4885KCNH2 3939/4885MLNR 1080/4885 |
| US-20230331703-A1 | EGFR INHIBITORS | EGFR, ERBB2, ERBB3 | EGFR 1/4885KCNH2 4598/4885MLNR 308/4885 |
| US-20210040068-A1 | EGFR INHIBITORS | EGFR, ERBB2, ERBB3 | EGFR 1/4885KCNH2 4449/4885MLNR 786/4885 |
| US-11639344-B2 | EGFR inhibitors | EGFR, ERBB2, ERBB3 | EGFR 1/4885KCNH2 4449/4885MLNR 786/4885 |
| US-10376512-B1 | Crystal of aniline pyrimidine compound of trifluoroethyl substituted indole and salt thereof | EGFR, ABL1, ERBB2 | EGFR 1/4885KCNH2 3934/4885MLNR 1665/4885 |
| US-20170355696-A1 | PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF | EGFR, WEE1, DPYD | EGFR 1/4885KCNH2 4122/4885MLNR 1233/4885 |
| US-12227491-B2 | EGFR inhibitors | EGFR, ERBB2, ERBB3 | EGFR 1/4885KCNH2 4539/4885MLNR 563/4885 |
| US-10179784-B2 | Pyrimidine or pyridine compounds, preparation method therefor and pharmaceutical uses thereof | EGFR, WEE1, DPYD | EGFR 1/4885KCNH2 3939/4885MLNR 1080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.