Befotertinib

Befotertinib

SCHEMBL29774263

C=CC(=O)Nc1cc(Nc2nccc(-c3cn(CC(F)(F)F)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 20/20 0.86
KCNH2 Q12809 2/20 0.80
MLNR O43193 1/20 0.80
KDM1A O60341 1/20 0.80
ABCB11 O95342 1/20 0.80
ERBB2 P04626 1/20 0.80
INSR P06213 1/20 0.80
CHRM2 P08172 1/20 0.80
HTR1A P08908 1/20 0.80
ADORA3 P0DMS8 1/20 0.80
DRD2 P14416 1/20 0.80
NQO2 P16083 1/20 0.80
ADRA2C P18825 1/20 0.80
DRD1 P21728 1/20 0.80
ERBB3 P21860 1/20 0.80
SLC6A2 P23975 1/20 0.80
HTR2A P28223 1/20 0.80
HTR2C P28335 1/20 0.80
ADORA2A P29274 1/20 0.80
SLC6A4 P31645 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Befotertinib SCHEMBL19337178 1.00 EGFR (0.86) EGFRKCNH2MLNRKDM1AABCB11
Befotertinib SCHEMBL30595515 1.00 EGFR (0.86) EGFRKCNH2MLNRKDM1AABCB11
Befotertinib SCHEMBL30354045 0.97 EGFR (0.82) EGFRKCNH2MLNRKDM1AABCB11
SCHEMBL19337200 0.95 EGFR (0.84) EGFRKCNH2MLNRKDM1AABCB11
SCHEMBL17553693 0.93 EGFR (0.91) EGFRKCNH2MLNRKDM1AABCB11
SCHEMBL17683310 0.93 EGFR (1.00) EGFRKCNH2MLNRKDM1AABCB11
SCHEMBL26554675 0.92 EGFR (0.73) EGFRKCNH2MLNRKDM1AABCB11
SCHEMBL22968448 0.92 EGFR (0.90) EGFRKCNH2MLNRKDM1AABCB11
SCHEMBL28412579 0.92 EGFR (0.91) EGFRKCNH2MLNRKDM1AABCB11
SCHEMBL28409356 0.92 EGFR (0.91) EGFRKCNH2MLNRKDM1AABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026103823-A1 COMBINATION OF RAS INHIBITOR AND EGFR INHIBITOR AND USE THEREOF 广州嘉越医药科技有限公司 2026-05-21 WO claimed
CN-122028932-A Use of bispecific antibody in preparation of medicine for treating cancer 上海翰森生物医药科技有限公司 2026-05-12 CN claimed
WO-2026086880-A1 PHARMACEUTICAL COMPOSITION OF EGFR INHIBITOR AND USE THEREOF 泰州红云制药有限公司 2026-04-30 WO claimed
US-20260021149-A1 METHOD FOR TREATMENT OF TUMOR BY USING RECOMBINANT ONCOLYTIC VIRUS IN COMBINATION WITH SMALL-MOLECULE ANTICANCER DRUG JOINT BIOSCIENCES SH LTD (CN) 2026-01-22 US claimed
US-20250188171-A1 COMBINATION THERAPY INCLUDING ANTIBODIES THAT BIND EGFR AND CMET WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-06-12 US claimed
US-20250179193-A1 TREATMENT WITH AN ANTIBODY THAT BINDS EGFR AND CMET WILMINGTON TRUST, NATIONAL ASSOCIATION 2025-06-05 US claimed
CN-120078896-A Combination therapy comprising antibodies that bind EGFR to cMET 美勒斯公司 2025-06-03 CN claimed
CN-120058955-A Treatment with antibodies that bind EGFR and cMET 美勒斯公司 2025-05-30 CN claimed
WO-2025105961-A1 COMBINATION THERAPY INCLUDING ANTIBODIES THAT BIND EGFR AND cMET. MERUS N.V. (NL) 2025-05-22 WO claimed
WO-2025067492-A1 USE OF BISPECIFIC ANTIBODY IN PREPARATION OF DRUG FOR TREATING CANCERS 上海翰森生物医药科技有限公司 2025-04-03 WO claimed
EP-4490190-A1 TREATMENT WITH AN ANTIBODY THAT BINDS EGFR AND CMET Merus N.V. (NL) 2025-01-15 EP claimed
CN-119278214-A Treatment with antibodies that bind EGFR and cMET 美勒斯公司 2025-01-07 CN claimed
CN-118974088-A Combination therapy comprising antibodies that bind EGFR to cMET 美勒斯公司 2024-11-15 CN claimed
EP-4424310-A1 ANTI-TUMOR PHARMACEUTICAL COMPOSITION COMPRISING AZVUDINE AND AN EGFR/TKI INHIBITOR Henan Genuine Biotech Co., Ltd. (CN) 2024-09-04 EP claimed
US-20240108633-A1 METHOD FOR PREVENTING OR TREATING DISEASE OR CONDITION ASSOCIATED WITH ANTITUMOR AGENT ONQUALITY PHARMACEUTICALS CHINA LTD. (CN) 2024-04-04 US claimed
US-11878028-B1 Anti-tumor pharmaceutical composition comprising azvudine HENAN GENUINE BIOTECH CO., LTD. (CN) 2024-01-23 US claimed
WO-2023172133-A1 COMBINATION THERAPY INCLUDING ANTIBODIES THAT BIND EGFR AND CMET MERUS N.V. (NL) 2023-09-14 WO claimed
WO-2023172134-A1 TREATMENT WITH AN ANTIBODY THAT BINDS EGFR AND CMET. MERUS N.V. (NL) 2023-09-14 WO claimed
CN-116710141-A Methods for preventing or treating antitumor agent-related diseases or conditions 上海岸阔医药科技有限公司 2023-09-05 CN claimed
WO-2022143628-A1 METHOD FOR PREVENTING OR TREATING DISEASE OR CONDITION ASSOCIATED WITH ANTITUMOR AGENT 上海岸阔医药科技有限公司 2022-07-07 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260021149-A1 METHOD FOR TREATMENT OF TUMOR BY USING RECOMBINANT ONCOLYTIC VIRUS IN COMBINATION WITH SMALL-MOLECULE ANTICANCER DRUG ERBB2, BTK, ERBB3 EGFR 5/4885KCNH2 3736/4885MLNR 1419/4885
US-20240108633-A1 METHOD FOR PREVENTING OR TREATING DISEASE OR CONDITION ASSOCIATED WITH ANTITUMOR AGENT JAK2, JAK1, JAK3 EGFR 439/4885KCNH2 347/4885MLNR 692/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.