Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Befotertinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 19/20 | 0.82 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.77 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.77 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.77 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.77 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.77 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.77 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.77 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.77 |
| ▸ | KDR known ✓ | P35968 | 1/20 | 0.77 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.77 |
| ▸ | GHSR known ✓ | Q92847 | 1/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.77 |
| ▸ | MLNR | O43193 | 1/20 | 0.77 |
| ▸ | KDM1A | O60341 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.77 |
| ▸ | INSR | P06213 | 1/20 | 0.77 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.77 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Befotertinib SCHEMBL30595515 | 0.97 | EGFR (0.86) | EGFRKCNH2MLNRKDM1AABCB11 | |
| Befotertinib SCHEMBL29774263 | 0.97 | EGFR (0.86) | EGFRKCNH2MLNRKDM1AABCB11 | |
| Befotertinib SCHEMBL19337178 | 0.97 | EGFR (0.86) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL19337200 | 0.92 | EGFR (0.84) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL28409189 | 0.92 | EGFR (0.86) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL17553693 | 0.91 | EGFR (0.91) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL17683310 | 0.90 | EGFR (1.00) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL26554675 | 0.90 | EGFR (0.73) | EGFRKCNH2MLNRKDM1AABCB11 | |
| Osimertinib SCHEMBL14661152 | 0.90 | EGFR (0.95) | EGFRKCNH2MLNRKDM1AABCB11 | |
| SCHEMBL22968448 | 0.90 | EGFR (0.90) | EGFRKCNH2MLNRKDM1AABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12227491-B2 | EGFR inhibitors | InventisBio Co., Ltd. (CN) | 2025-02-18 | — | — | US | claimed |
| US-20230331703-A1 | EGFR INHIBITORS | InventisBio Co., Ltd. (CN) | 2023-10-19 | — | — | US | claimed |
| US-12227491-B2 | EGFR inhibitors | InventisBio Co., Ltd. (CN) | 2025-02-18 | — | — | US | disclosed |
| US-20230331703-A1 | EGFR INHIBITORS | InventisBio Co., Ltd. (CN) | 2023-10-19 | — | — | US | disclosed |
| US-11639344-B2 | EGFR inhibitors | InventisBio Co., Ltd. (CN) | 2023-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230331703-A1 | EGFR INHIBITORS | EGFR, ERBB2, ERBB3 | EGFR 1/4885HTR1A 526/4885DRD2 4169/4885 |
| US-11639344-B2 | EGFR inhibitors | EGFR, ERBB2, ERBB3 | EGFR 1/4885HTR1A 724/4885DRD2 4430/4885 |
| US-12227491-B2 | EGFR inhibitors | EGFR, ERBB2, ERBB3 | EGFR 1/4885HTR1A 566/4885DRD2 3965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.