Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9990716 | 1.00 | HTR6 (0.38) | HTR6BCHEALDH1A1USP30POLB | |
| SCHEMBL28589631 | 0.93 | USP30 (0.44) | HTR6BCHEALDH1A1USP30POLB | |
| SCHEMBL1935238 | 0.93 | USP30 (0.44) | HTR6BCHEALDH1A1USP30POLB | |
| SCHEMBL18832817 | 0.89 | ALDH1A1 (0.39) | ALDH1A1POLBNPC1RAB9AMEN1 | |
| SCHEMBL1935172 | 0.88 | GPR119 (0.39) | HTR6USP30MMP13GPR119TGM2 | |
| SCHEMBL1933877 | 0.84 | USP30 (0.39) | HTR6USP30MMP13GPR119TGM2 | |
| SCHEMBL4355056 | 0.84 | USP30 (0.39) | HTR6USP30MMP13GPR119TGM2 | |
| SCHEMBL9990721 | 0.83 | HTR6 (0.42) | HTR6BCHEALDH1A1POLBMMP13 | |
| SCHEMBL1934083 | 0.83 | HTR6 (0.42) | HTR6BCHEALDH1A1POLBMMP13 | |
| SCHEMBL1935242 | 0.81 | HTR6 (0.43) | HTR6BCHEALDH1A1MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506716-A1 | NOVEL TRICYCLIC COMPOUNDS | Abbott Laboratories (US) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011068881-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |