Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19342217 | 0.89 | DDB1 (0.40) | DDB1CRBNPRMT5WDR77ALDH1A1 | |
| SCHEMBL19005807 | 0.87 | ALDH1A1 (0.43) | DDB1CRBNALDH1A1KDM4EGLA | |
| SCHEMBL19331754 | 0.87 | DDB1 (0.44) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL12320881 | 0.85 | DDB1 (0.42) | DDB1CRBNALDH1A1KDM4EMAPT | |
| SCHEMBL4739542 | 0.81 | PARP1 (0.45) | KDM4EMEN1KMT2AGPR119PDK4 | |
| SCHEMBL20163723 | 0.81 | DDB1 (0.42) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL16825886 | 0.80 | DDB1 (0.43) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL31732367 | 0.78 | DDB1 (0.41) | DDB1CRBNALDH1A1KDM4EGLA | |
| SCHEMBL29124107 | 0.78 | FAAH (0.40) | DDB1CRBNALDH1A1KDM4EHPGD | |
| SCHEMBL20971792 | 0.77 | DDB1 (0.41) | DDB1CRBNALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156177-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |