Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19344109 | 0.89 | PHGDH (0.53) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19347345 | 0.81 | PHGDH (0.51) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19332488 | 0.78 | SLC9A1 (0.46) | PHGDHKDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL19343635 | 0.78 | PHGDH (0.55) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19331035 | 0.77 | RHEB (0.47) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19346013 | 0.77 | PHGDH (0.41) | PHGDH | |
| SCHEMBL19331801 | 0.77 | PHGDH (0.41) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19344152 | 0.76 | PHGDH (0.53) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19331188 | 0.76 | L3MBTL1 (0.51) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL25538844 | 0.75 | PHGDH (0.57) | PHGDHHSD17B10MAPTTP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156177-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |