SCHEMBL1934302

SCHEMBL1934302

FCOc1cccc(Cl)c1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
WDR5 P61964 1/20 0.55
LMNA P02545 1/20 0.53
MAPK1 P28482 1/20 0.53
HTT P42858 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
MAOB P27338 1/20 0.51
AOC3 Q16853 1/20 0.51
DRD2 P14416 1/20 0.50
DRD4 P21917 1/20 0.50
KMT2A Q03164 3/20 0.49
KCNH2 Q12809 1/20 0.49
RXRA P19793 1/20 0.47
RXRB P28702 1/20 0.47
RXRG P48443 1/20 0.47
KDM4E B2RXH2 2/20 0.46
MEN1 O00255 1/20 0.46
HRH3 Q9Y5N1 3/20 0.45
CYP2D6 P10635 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4737237 0.84 TP53 (0.45) LMNAMAPK1SMN1; SMN2MAOB
SCHEMBL10458289 0.83 LMNA (0.59) WDR5LMNAMAPK1HTTSMN1; SMN2
SCHEMBL9808215 0.82 LMNA (0.67) WDR5LMNAMAPK1HTTSMN1; SMN2
SCHEMBL11833932 0.80 WDR5 (0.56) WDR5LMNAMAPK1HTTSMN1; SMN2
SCHEMBL21742155 0.78 WDR5 (0.59) WDR5LMNAMAPK1HTTSMN1; SMN2
SCHEMBL3889573 0.78 WDR5 (0.55) WDR5LMNAMAPK1HTTSMN1; SMN2
SCHEMBL2096238 0.78 WDR5 (0.55) WDR5LMNAMAPK1HTTSMN1; SMN2
SCHEMBL2096242 0.78 WDR5 (0.59) WDR5LMNAMAPK1HTTSMN1; SMN2
SCHEMBL535552 0.78 WDR5 (0.55) WDR5LMNAMAPK1HTTSMN1; SMN2
SCHEMBL30167806 0.78 TP53 (0.59) WDR5LMNAMAPK1HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2892898-A1 7-HYDROXY-SPIROPIPIPERIDINE INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR Bristol-Myers Squibb Company (US) 2015-07-15 EP disclosed
EP-2504324-B1 SULTAM DERIVATIVES HOFFMANN LA ROCHE (CH) 2015-02-25 EP disclosed
EP-2755944-A2 ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION Fovea Pharmaceuticals (FR) 2014-07-23 EP disclosed
WO-2014022349-A1 7-HYDROXY-SPIROPIPIPERIDINE INDOLINYL ANTAGONISTS OF P2Y1 RECEPTOR BRISTOL-MYERS SQUIBB COMPANY (US) 2014-02-06 WO disclosed
WO-2013037705-A9 ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION FOVEA PHARMACEUTICALS (FR) 2013-09-06 WO disclosed
WO-2013037705-A2 ANILINE DERIVATIVES,THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION FOVEA PHARMACEUTICALS (FR) 2013-03-21 WO disclosed
EP-2504324-A1 SULTAM DERIVATIVES F. Hoffmann-La Roche AG (CH) 2012-10-03 EP disclosed
WO-2011064141-A1 SULTAM DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2011-06-03 WO disclosed
EP-1863794-A2 PYRIMIDINE COMPOUNDS AND METHODS OF USE Targegen, Inc. (US) 2007-12-12 EP disclosed
EP-1809614-A2 BENZOTRIAZINE INHIBITORS OF KINASES Targegen, Inc. (US) 2007-07-25 EP disclosed
WO-2006101977-A2 PYRIMIDINE COMPOUNDS AND METHODS OF USE TARGEGEN, INC. (US) 2006-09-28 WO disclosed
WO-2005096784-A2 BENZOTRIAZINE INHIBITORS OF KINASES TARGEGEN, INC. (US) 2005-10-20 WO disclosed