Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | NNMT | P40261 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25495954 | 0.83 | PRMT5 (0.47) | ADKPRMT5WDR77NNMTADORA3 | |
| SCHEMBL22434979 | 0.82 | ADK (0.52) | ADKADORA3ADORA2AADORA1 | |
| SCHEMBL22434980 | 0.82 | ADK (0.52) | ADKADORA3ADORA2AADORA1 | |
| SCHEMBL14644657 | 0.80 | ADK (0.47) | ADKABL1RIN1CSF1RPOLB | |
| SCHEMBL25495949 | 0.79 | PRMT5 (0.43) | PRMT5WDR77NNMT | |
| SCHEMBL25495952 | 0.79 | PRMT5 (0.47) | PRMT5WDR77NNMT | |
| SCHEMBL25496133 | 0.79 | PRMT5 (0.47) | PRMT5WDR77NNMT | |
| SCHEMBL19344247 | 0.77 | PRMT5 (0.38) | ADKPRMT5WDR77ADORA3ADORA2A | |
| SCHEMBL1798411 | 0.76 | ADK (0.54) | ADKPOLBADORA3ADORA2A | |
| SCHEMBL25996051 | 0.76 | ADK (0.54) | ADKPOLBADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |