Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 5/20 | 0.32 |
| ▸ | JAK2 | O60674 | 4/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 6/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584611 | 0.89 | PRMT5 (0.30) | — | |
| SCHEMBL22434806 | 0.87 | CNR2 (0.37) | CNR2JAK1JAK2NAMPTCNR1 | |
| SCHEMBL23584795 | 0.87 | CNR2 (0.37) | CNR2JAK1JAK2NAMPTCNR1 | |
| SCHEMBL23584737 | 0.86 | CNR2 (0.38) | CNR2NAMPTCNR1GPR119 | |
| SCHEMBL19344515 | 0.86 | CNR2 (0.32) | CNR2JAK1JAK2 | |
| SCHEMBL23584687 | 0.78 | PRMT5 (0.36) | — | |
| SCHEMBL23584806 | 0.76 | CNR2 (0.37) | CNR2NAMPTCNR1GPR119 | |
| SCHEMBL24606323 | 0.75 | TSHR (0.32) | — | |
| SCHEMBL19344517 | 0.74 | PRMT5 (0.31) | — | |
| SCHEMBL23584658 | 0.74 | CNR2 (0.37) | CNR2CNR1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |