Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 3/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584762 | 0.88 | CNR2 (0.39) | CNR2GPR119PRMT5SRCEGFR | |
| SCHEMBL23584786 | 0.88 | PRMT5 (0.47) | CNR2GPR119PRMT5SRCEGFR | |
| SCHEMBL22435021 | 0.84 | PRMT5 (0.35) | CNR2GPR119PRMT5CYP3A4CYP2C9 | |
| SCHEMBL19343960 | 0.84 | PRMT5 (0.35) | CNR2GPR119PRMT5CYP3A4CYP2C9 | |
| SCHEMBL23584649 | 0.82 | PRMT5 (0.32) | CNR2PRMT5 | |
| SCHEMBL25047907 | 0.82 | GPR119 (0.39) | CNR2GPR119PRMT5CCNA2CDK2 | |
| SCHEMBL25047504 | 0.79 | JAK3 (0.40) | CNR2GPR119PRMT5CCNA2CDK2 | |
| SCHEMBL25048811 | 0.77 | GPR119 (0.40) | CNR2GPR119PRMT5SRCEGFR | |
| SCHEMBL19344204 | 0.76 | PRMT5 (0.39) | CNR2GPR119PRMT5CYP3A4CYP2C9 | |
| SCHEMBL23584748 | 0.76 | GPR119 (0.40) | CNR2GPR119PRMT5CNR1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |