SCHEMBL1934569

SCHEMBL1934569

N#Cc1cc(-c2cccc(C(F)(F)F)c2F)ccn1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
AR P10275 4/20 0.43
MPL P40238 3/20 0.42
TGFBR1 P36897 1/20 0.39
GRM2 Q14416 1/20 0.39
MYC P01106 1/20 0.39
NPY5R Q15761 1/20 0.38
PGR P06401 1/20 0.38
SCN9A Q15858 1/20 0.37
ALOX5AP P20292 1/20 0.37
FEN1 P39748 1/20 0.37
GRIN1 Q05586 1/20 0.37
GRIN2B Q13224 1/20 0.37
NR1H2 P55055 1/20 0.37
NR1H3 Q13133 1/20 0.37
CTSS P25774 1/20 0.37
XDH P47989 1/20 0.36
ABCG2 Q9UNQ0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1935087 0.87 AR (0.57) ARTGFBR1GRM2MYCPGR
SCHEMBL1936006 0.81 TRPA1 (0.49) ARGRM2MYCNPY5RPGR
SCHEMBL1935634 0.81 TRPA1 (0.49) TGFBR1GRM2MYCNPY5RSCN9A
SCHEMBL1935090 0.79 TRPA1 (0.48) ARGRM2MYCNPY5RSCN9A
SCHEMBL1936046 0.79 TRPA1 (0.48) ARGRM2MYCNPY5RALOX5AP
SCHEMBL1933954 0.76 ALOX5AP (0.49) TGFBR1MYCNPY5RALOX5APFEN1
SCHEMBL1936365 0.76 ALOX5AP (0.44) ARGRM2MYCNPY5RSCN9A
SCHEMBL1934845 0.76 GRM2 (0.42) ARGRM2MYCNPY5RSCN9A
SCHEMBL1936074 0.75 MYC (0.48) ARMPLMYCNPY5RPGR
SCHEMBL1934802 0.75 GRM2 (0.43) ARGRM2MYCSCN9AXDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2332936-B1 PYRIDINE COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL CO (JP) 2013-09-04 EP disclosed
EP-2332936-B1 PYRIDINE COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL CO (JP) 2013-09-04 EP disclosed
US-20110178132-A1 PYRIDINE COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2011-07-21 US disclosed
US-20110178132-A1 PYRIDINE COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2011-07-21 US disclosed
US-20110178132-A1 PYRIDINE COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY LIMITED (JP) 2011-07-21 US disclosed
EP-2332936-A1 PYRIDINE COMPOUND AND USE THEREOF FOR PEST CONTROL Sumitomo Chemical Company, Limited (JP) 2011-06-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110178132-A1 PYRIDINE COMPOUND AND USE THEREOF FOR PEST CONTROL C5, PRDX1, PRDX4 AR 4124/4885MPL 3986/4885TGFBR1 2587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.