⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19346703 | 0.84 | — | — | |
| SCHEMBL23351061 | 0.81 | — | — | |
| SCHEMBL19346490 | 0.79 | POLB (0.31) | — | |
| SCHEMBL23351001 | 0.79 | — | — | |
| SCHEMBL19346484 | 0.77 | — | — | |
| SCHEMBL19346485 | 0.74 | MAPK1 (0.33) | — | |
| SCHEMBL22745239 | 0.65 | POLB (0.34) | — | |
| SCHEMBL22193802 | 0.64 | NLRP3 (0.36) | — | |
| SCHEMBL22745249 | 0.62 | POLB (0.38) | — | |
| SCHEMBL20123748 | 0.61 | ALOX15 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426656-B1 | TRICYCLIC COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2021-05-12 | — | — | EP | disclosed |
| WO-2017153919-A1 | TRICYCLIC COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2017-09-14 | — | — | WO | disclosed |