Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22745249 | 0.84 | POLB (0.38) | POLBGAATDP1NPC1LMNA | |
| SCHEMBL19346563 | 0.78 | GAA (0.30) | GAA | |
| SCHEMBL28396680 | 0.70 | NLRP3 (0.39) | NLRP3POLBGAAALOX5ALOX5AP | |
| SCHEMBL24978765 | 0.70 | NLRP3 (0.37) | NLRP3ALOX5ALOX5APFEN1 | |
| SCHEMBL22745500 | 0.70 | POLB (0.40) | POLBGAATDP1NPC1LMNA | |
| SCHEMBL16559294 | 0.68 | XIAP (0.34) | — | |
| SCHEMBL20939381 | 0.68 | NLRP3 (0.42) | NLRP3ALOX5ALOX5APFEN1 | |
| SCHEMBL22745239 | 0.68 | POLB (0.34) | POLBGAATDP1NPC1LMNA | |
| SCHEMBL22745259 | 0.68 | POLB (0.34) | POLBGAATDP1NPC1LMNA | |
| SCHEMBL20400046 | 0.67 | NLRP3 (0.39) | NLRP3ALOX5ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3778603-A1 | 7,8-DIHYDRO-3H-PYRAZINO[1,2-B]PYRIDAZINE-3,5(6H)-DIONE COMPOUNDS AND USES THEREOF | Janssen BioPharma, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3030566-B1 | 7,8-DIHYDRO-3H-PYRAZINO[1,2-B]PYRIDAZINE-3,5(6H)-DIONE COMPOUNDS AND USES THEREOF | JANSSEN BIOPHARMA INC (US) | 2020-07-08 | — | — | EP | disclosed |