Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.53 |
| ▸ | SLC28A1 | O00337 | 2/20 | 0.50 |
| ▸ | PI4KA | P42356 | 2/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.50 |
| ▸ | GMPS | P49915 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.50 |
| ▸ | GAPDH | P04406 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831039 | 0.89 | ADORA3 (0.53) | ADORA3ADORA2ASLC28A1PI4KAPI4K2B | |
| SCHEMBL29401884 | 0.89 | ADORA3 (0.53) | ADORA3ADORA2ASLC28A1PI4KAPI4K2B | |
| SCHEMBL31160173 | 0.88 | LMNA (0.40) | ADORA3ADORA2ASLC28A1PI4KAPI4K2B | |
| SCHEMBL10776201 | 0.85 | ADORA3 (0.49) | ADORA3ADORA2ASLC28A1PI4KAPI4K2B | |
| SCHEMBL28360308 | 0.84 | P2RY1 (0.49) | ADORA1SMN1; SMN2 | |
| SCHEMBL6513952 | 0.83 | ADORA3 (0.48) | ADORA3ADORA2ASLC28A1PI4KAPI4K2B | |
| SCHEMBL6513941 | 0.83 | ADORA3 (0.48) | ADORA3ADORA2ASLC28A1PI4KAPI4K2B | |
| SCHEMBL29508945 | 0.83 | ADORA3 (0.53) | ADORA3ADORA2ASLC28A1PI4KAPI4K2B | |
| SCHEMBL4944757 | 0.83 | ADORA3 (0.53) | ADORA3ADORA2ASLC28A1PI4KAPI4K2B | |
| SCHEMBL481525 | 0.82 | ADORA3 (0.55) | ADORA3ADORA2ASLC28A1PI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197457-B1 | 4'-VINYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS RNA REPLICATION | RIBOSCIENCE LLC (US) | 2022-11-09 | — | — | EP | disclosed |
| US-11446398-B2 | Regulated biocircuit systems | OBSIDIAN THERAPEUTICS, INC. (US) | 2022-09-20 | — | — | US | disclosed |
| US-20190192691-A1 | REGULATED BIOCIRCUIT SYSTEMS | OBSIDIAN THERAPEUTICS, INC. | 2019-06-27 | — | — | US | disclosed |
| EP-1540013-B1 | EVOLVING NEW MOLECULAR FUNCTION | HARVARD COLLEGE (US) | 2015-07-08 | — | — | EP | disclosed |
| EP-1423400-B2 | EVOLVING NEW MOLECULAR FUNCTION | HARVARD COLLEGE (US) | 2013-05-22 | — | — | EP | disclosed |
| US-20120165228-A1 | EVOLVING NEW MOLECULAR FUNCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2012-06-28 | — | — | US | disclosed |
| US-8206914-B2 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-26 | — | — | US | disclosed |
| US-7998904-B2 | Libraries of oligonucleotides created by genetic engineering | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-08-16 | — | — | US | disclosed |
| US-20110190141-A1 | Evolving New Molecular Function | PRESIDENT AND FELLOWS OF HAVARD COLLEGE (US) | 2011-08-04 | — | — | US | disclosed |
| EP-2332896-A2 | Evolving new molecular function | President and Fellows of Harvard College (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20050142583-A1 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-06-30 | — | — | US | disclosed |
| EP-1540013-A2 | EVOLVING NEW MOLECULAR FUNCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20050042669-A1 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-02-24 | — | — | US | disclosed |
| US-20050025766-A1 | Evolving new molecular function | LIU DAVID R (US) | 2005-02-03 | — | — | US | disclosed |
| EP-1423400-A4 | EVOLVING NEW MOLECULAR FUNCTION | HARVARD COLLEGE (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20040180412-A1 | Evolving new molecular function | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-09-16 | — | — | US | disclosed |
| EP-1423400-A2 | EVOLVING NEW MOLECULAR FUNCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2004016767-A2 | EVOLVING NEW MOLECULAR FUNCTION | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-02-26 | — | — | WO | disclosed |
| US-20030113738-A1 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2003-06-19 | — | — | US | disclosed |
| WO-2002074929-A2 | EVOLVING NEW MOLECULAR FUNCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050025766-A1 | Evolving new molecular function | POLI, PCNA, POLK | ADORA3 1761/4885ADORA2A 1913/4885SLC28A1 3989/4885 |
| US-20120165228-A1 | EVOLVING NEW MOLECULAR FUNCTION | POLI, PCNA, POLK | ADORA3 1761/4885ADORA2A 1913/4885SLC28A1 3989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.