Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | PHGDH | O43175 | 10/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19342030 | 0.96 | PHGDH (0.47) | DRD2PHGDHKDM4EALDH1A1HSD17B10 | |
| SCHEMBL26326346 | 0.84 | PHGDH (0.51) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19343635 | 0.81 | PHGDH (0.55) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19344109 | 0.79 | PHGDH (0.53) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL25538844 | 0.79 | PHGDH (0.57) | PHGDHHSD17B10 | |
| SCHEMBL20793451 | 0.79 | PHGDH (0.53) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19347589 | 0.78 | PHGDH (0.45) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL20768544 | 0.77 | PHGDH (0.64) | PHGDH | |
| SCHEMBL25535260 | 0.76 | PHGDH (0.44) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL25536534 | 0.76 | PHGDH (0.49) | PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156179-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |