Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 14/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26326346 | 0.82 | PHGDH (0.51) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19347589 | 0.80 | PHGDH (0.45) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19347345 | 0.80 | PHGDH (0.51) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19343635 | 0.79 | PHGDH (0.55) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19347346 | 0.79 | PHGDH (0.49) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19344109 | 0.77 | PHGDH (0.53) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19344152 | 0.77 | PHGDH (0.53) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL25538844 | 0.77 | PHGDH (0.57) | PHGDHHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL19347347 | 0.76 | DRD2 (0.46) | PHGDHKDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19347583 | 0.76 | PHGDH (0.44) | PHGDHKDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426244-B1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS INC (US) | 2023-06-07 | — | — | EP | disclosed |