Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7042649 | 0.79 | ESR1 (0.56) | ESR1ESR2MAPTPTGS2CA1 | |
| SCHEMBL5193971 | 0.75 | ESR1 (0.73) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL12501933 | 0.74 | MAPT (0.50) | MEN1HSP90AA1KMT2AMAPTCHEK1 | |
| SCHEMBL7042915 | 0.72 | ESR1 (0.79) | ESR1ESR2MAPTPTGS2CHEK1 | |
| SCHEMBL7038621 | 0.72 | ESR1 (0.79) | ESR1ESR2MAPTPTGS2CHEK1 | |
| SCHEMBL30873777 | 0.72 | IMPDH2 (0.63) | MEN1KMT2AMAPTCA1CA2 | |
| SCHEMBL3874953 | 0.72 | IMPDH2 (0.63) | MEN1KMT2AMAPTCA1CA2 | |
| SCHEMBL28583369 | 0.71 | NQO1 (0.59) | ESR1ESR2MEN1HSP90AA1KMT2A | |
| SCHEMBL7041577 | 0.71 | ESR1 (0.73) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL3085172 | 0.70 | ESR1 (0.49) | ESR1ESR2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011066606-A1 | PYRANOINDOLE COMPOUNDS AND USES THEREOF | NOVOGEN RESEARCH PTY LTD (AU) | 2011-06-09 | — | — | WO | disclosed |