Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | CDK1 | P06493 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28657494 | 0.80 | ESR1 (0.49) | ESR1ESR2PTGS2CHEK1CDK1 | |
| SCHEMBL22326302 | 0.71 | ALDH1A1 (0.44) | MAPK1NPSR1KDM4EMAPTMEN1 | |
| SCHEMBL7624177 | 0.70 | ESR1 (0.52) | ESR1ESR2PTGS2MAPK1NPSR1 | |
| SCHEMBL1934974 | 0.70 | ESR1 (0.53) | ESR1ESR2PTGS2CHEK1CDK1 | |
| SCHEMBL18610257 | 0.69 | ESR1 (0.73) | ESR1ESR2PTGS2EGFRKDM4E | |
| SCHEMBL7991776 | 0.68 | ALDH1A1 (0.41) | MAPK1NPSR1KDM4EMAPTMEN1 | |
| SCHEMBL2224694 | 0.67 | ESR1 (0.44) | ESR1ESR2PTGS2NPSR1KDM4E | |
| SCHEMBL28983296 | 0.67 | ESR1 (0.58) | ESR1ESR2PTGS2CHEK1CDK1 | |
| SCHEMBL29965835 | 0.67 | ESR1 (0.44) | ESR1ESR2PTGS2NPSR1KDM4E | |
| SCHEMBL3278733 | 0.66 | ESR1 (0.62) | ESR1ESR2MAPK1NPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2316927-B1 | KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS | HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT GMBH (DE) | 2014-11-05 | — | — | EP | disclosed |
| US-8409809-B2 | KASPP (LRRK2) gene, its production and use for the detection and treatment of neurodegenerative disorders | HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) (DE) | 2013-04-02 | — | — | US | disclosed |
| EP-1802749-B1 | KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS | HELMHOLTZ ZENTRUM MUENCHEN (DE) | 2012-08-22 | — | — | EP | disclosed |
| US-20100235933-A1 | Kaspp (lrrk2) gene, its production and use for the detection and treatment of neurodegenerative disorders | MAYO CLINIC (US) | 2010-09-16 | — | — | US | disclosed |
| EP-1802749-A2 | KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS | GSF-FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT, GMBH (DE) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006045392-A2 | KASPP (LRRKE) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH (DE) | 2006-05-04 | — | — | WO | disclosed |