Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | BCR | P11274 | 2/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17634853 | 0.93 | PRKDC (0.42) | PRKDCCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL19355265 | 0.87 | PRKDC (0.40) | RIPK1PRKDCCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19905303 | 0.87 | CYP1A2 (0.39) | ABL1BCRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17634849 | 0.87 | PRKDC (0.44) | PRKDCCYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL19355149 | 0.87 | PRKDC (0.39) | PRKDCABL1BCRCYP1A2CYP3A4 | |
| SCHEMBL19355624 | 0.86 | GCK (0.39) | PRKDCABL1BCRPIK3CAFEN1 | |
| SCHEMBL19355131 | 0.85 | HPGDS (0.33) | RIPK1PRKDCABL1BCRRPS6KB1 | |
| SCHEMBL19355582 | 0.85 | PRKDC (0.39) | PRKDC | |
| SCHEMBL19905204 | 0.84 | PRKDC (0.37) | PRKDCABL1BCRCYP1A2CYP3A4 | |
| SCHEMBL19355613 | 0.84 | PRKDC (0.42) | PRKDCABL1BCRCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170258789-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170258789-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | RIPK1 1528/4885PRKDC 33/4885ABL1 713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.