Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 7/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 3/20 | 0.31 |
| ▸ | BCR | P11274 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | KMO | O15229 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15356597 | 0.92 | PRKDC (0.47) | PRKDCFAAHPTGS2ALOX5APFEN1 | |
| SCHEMBL19905204 | 0.90 | PRKDC (0.37) | PRKDCFAAHCYP1A2CLK4ABL1 | |
| SCHEMBL19355624 | 0.88 | GCK (0.39) | PRKDCFAAHFEN1ABL1BCR | |
| SCHEMBL19355582 | 0.88 | PRKDC (0.39) | PRKDC | |
| SCHEMBL19905352 | 0.88 | PRKDC (0.41) | PRKDCFAAHALOX5APFEN1ABL1 | |
| SCHEMBL19355141 | 0.87 | PRKDC (0.36) | PRKDCFAAHCYP1A2CLK4ABL1 | |
| SCHEMBL19355648 | 0.87 | PRKDC (0.38) | PRKDCFAAHALOX5APFEN1ABL1 | |
| SCHEMBL19355306 | 0.87 | PRKDC (0.38) | PRKDCFAAHFEN1KDM4E | |
| SCHEMBL19355142 | 0.87 | RIPK1 (0.37) | PRKDCALOX5APFEN1CYP1A2CLK4 | |
| SCHEMBL19355509 | 0.86 | PRKDC (0.38) | PRKDCFAAHABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170258789-A1 | DNA-PK INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170258789-A1 | DNA-PK INHIBITORS | POLK, DTYMK, DCK | PRKDC 33/4885FAAH 3955/4885PTGS2 2079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.