Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.55 |
| ▸ | HTR1A known ✓ | P08908 | 5/20 | 0.55 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.55 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.55 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 2/20 | 0.53 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.84 |
| ▸ | MEN1 | O00255 | 1/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.84 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.84 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.84 |
| ▸ | TSHR | P16473 | 1/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.84 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.84 |
| ▸ | DRD3 | P35462 | 7/20 | 0.57 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1935565 | 1.00 | MAPT (0.84) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2216839 | 0.92 | MAPT (1.00) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5431884 | 0.86 | MAPT (0.88) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5432917 | 0.81 | MAPT (0.79) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5423905 | 0.81 | MAPT (0.79) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5430105 | 0.81 | MAPT (0.79) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5435317 | 0.80 | MAPT (0.78) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5438985 | 0.77 | MEN1 (0.73) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9825818 | 0.76 | MEN1 (0.67) | MAPTMEN1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9825826 | 0.76 | MEN1 (0.67) | MAPTMEN1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10620222-B2 | Electrified compositions for determining the risk of developing adolescent idiopathic scoliosis through the use of GI protein receptor | CHU SAINTE-JUSTINE (CA) | 2020-04-14 | — | — | US | claimed |
| US-20160146839-A1 | METHODS FOR THE CLASSIFICATION AND DIAGNOSIS OF SCOLIOSIS THROUGH THE USE OF GI PROTEIN RECEPTOR | CHU SAINTE-JUSTINE (CA) | 2016-05-26 | — | — | US | claimed |
| WO-2010040234-A1 | METHODS FOR THE CLASSIFICATION AND DIAGNOSIS OF SCOLIOSIS | CHU SAINTE-JUSTINE (CA) | 2010-04-15 | — | — | WO | claimed |
| EP-3647789-A1 | NEW MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS | Chu Sainte-Justine (CA) | 2020-05-06 | — | — | EP | disclosed |
| US-10620222-B2 | Electrified compositions for determining the risk of developing adolescent idiopathic scoliosis through the use of GI protein receptor | CHU SAINTE-JUSTINE (CA) | 2020-04-14 | — | — | US | disclosed |
| EP-3044321-B1 | NEW MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS | CHU SAINTE JUSTINE (CA) | 2019-07-31 | — | — | EP | disclosed |
| US-20190178896-A1 | MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS | CHU SAINTE-JUSTINE (CA) | 2019-06-13 | — | — | US | disclosed |
| US-10247737-B2 | Kits for classifying a subject having or at risk for developing idiopathic scoliosis | CHU SAINTE-JUSTINE (CA) | 2019-04-02 | — | — | US | disclosed |
| US-20160216277-A1 | NEW MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS | CHU SAINTE-JUSTINE (CA) | 2016-07-28 | — | — | US | disclosed |
| EP-3044321-A1 | NEW MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS | Chu Sainte-Justine (CA) | 2016-07-20 | — | — | EP | disclosed |
| US-20160146839-A1 | METHODS FOR THE CLASSIFICATION AND DIAGNOSIS OF SCOLIOSIS THROUGH THE USE OF GI PROTEIN RECEPTOR | CHU SAINTE-JUSTINE (CA) | 2016-05-26 | — | — | US | disclosed |
| WO-2015032005-A1 | NEW MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS | CHU-SAINTE-JUSTINE (CA) | 2015-03-12 | — | — | WO | disclosed |
| US-20110195436-A1 | METHODS FOR THE CLASSIFICATION AND DIAGNOSIS OF SCOLIOSIS THROUGH THE USE OF GI PROTEIN RECEPTOR | Fourth Dimension Spine, LLC | 2011-08-11 | — | — | US | disclosed |
| EP-2331962-A1 | METHODS FOR THE CLASSIFICATION AND DIAGNOSIS OF SCOLIOSIS THROUGH THE USE OF GI PROTEIN RECEPTOR | Chu Sainte-Justine (CA) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010040234-A1 | METHODS FOR THE CLASSIFICATION AND DIAGNOSIS OF SCOLIOSIS | CHU SAINTE-JUSTINE (CA) | 2010-04-15 | — | — | WO | disclosed |