Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19359442 | 0.79 | LMNA (0.51) | LMNANPSR1HTTTP53GAA | |
| SCHEMBL19359166 | 0.78 | MPO (0.46) | LMNANPSR1HTTTP53ALDH1A1 | |
| SCHEMBL19636582 | 0.76 | LMNA (0.76) | LMNANPSR1HTTTP53GAA | |
| SCHEMBL19359538 | 0.76 | CNR2 (0.45) | LMNATP53GAA | |
| SCHEMBL19359493 | 0.76 | LMNA (0.48) | LMNANPSR1HTTTP53GAA | |
| SCHEMBL19359266 | 0.74 | POLB (0.42) | LMNATP53ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL19359496 | 0.73 | SMPD1 (0.42) | HTTSMN1; SMN2MAPK1KMT2A | |
| SCHEMBL22423851 | 0.73 | SMPD1 (0.42) | HTTSMN1; SMN2MAPK1KMT2A | |
| SCHEMBL19380989 | 0.69 | PKM (0.45) | LMNANPSR1HTTTP53GAA | |
| SCHEMBL19359262 | 0.69 | PKM (0.45) | LMNANPSR1HTTTP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161145-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE AND/OR EPX | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-21 | — | — | WO | disclosed |