Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.79 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.60 |
| ▸ | F3 | P13726 | 3/20 | 0.58 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | OXTR | P30559 | 1/20 | 0.58 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.58 |
| ▸ | CD81 | P60033 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.53 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.53 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.53 |
| ▸ | PTPRC | P08575 | 2/20 | 0.53 |
| ▸ | PTPRF | P10586 | 2/20 | 0.53 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15883013 | 0.92 | PTPN1 (0.79) | PTPN1AKR1B10AKR1B1ALOX5F3 | |
| Barringtogenol C SCHEMBL15132635 | 0.92 | PTPN1 (0.81) | PTPN1AKR1B10AKR1B1ALOX5F3 | |
| Barringtogenol C SCHEMBL14871943 | 0.92 | PTPN1 (0.81) | PTPN1AKR1B10AKR1B1ALOX5F3 | |
| Barringtogenol C SCHEMBL1049164 | 0.92 | PTPN1 (0.81) | PTPN1AKR1B10AKR1B1ALOX5F3 | |
| SCHEMBL13559844 | 0.91 | PTPN1 (0.66) | PTPN1AKR1B10AKR1B1ALOX5F3 | |
| SCHEMBL29934333 | 0.88 | PTPN1 (1.00) | PTPN1AKR1B10AKR1B1ALOX5F3 | |
| SCHEMBL19284333 | 0.88 | PTPN1 (1.00) | PTPN1AKR1B10AKR1B1ALOX5F3 | |
| SCHEMBL13559839 | 0.86 | PTPN1 (0.63) | PTPN1AKR1B10AKR1B1ALOX5F3 | |
| SCHEMBL18407010 | 0.84 | PTPN1 (0.58) | PTPN1ALOX5F3SIRT5CYP3A4 | |
| SCHEMBL15883003 | 0.84 | PTPN1 (0.66) | PTPN1AKR1B10AKR1B1ALOX5F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170267714-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | PACIFIC ARROW LTD (CN) | 2017-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267714-A1 | NATURAL AND SYNTHETIC COMPOUNDS FOR TREATING CANCER AND OTHER DISEASES | VCAM1, EPCAM, ICAM1 | PTPN1 2251/4885AKR1B10 3168/4885AKR1B1 3598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.