Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 4/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365583 | 0.91 | ABL1 (0.38) | SLC6A9SLC6A5ALDH1A1IGF1RGRM5 | |
| SCHEMBL19364834 | 0.89 | ALDH1A1 (0.39) | SLC6A9SLC6A5ALDH1A1NPC1 | |
| SCHEMBL21841343 | 0.84 | KMO (0.41) | ALDH1A1RAB9A | |
| SCHEMBL19365469 | 0.84 | GRM4 (0.40) | SLC6A9BTK | |
| SCHEMBL19365441 | 0.84 | ATR (0.48) | LMNANPC1RAB9A | |
| SCHEMBL19670601 | 0.84 | POLB (0.41) | ALDH1A1RAB9A | |
| SCHEMBL19365710 | 0.83 | CNR2 (0.52) | ALDH1A1LMNAGRM5 | |
| SCHEMBL19365794 | 0.83 | ATR (0.38) | ALDH1A1BTKNPC1RAB9AGRM5 | |
| SCHEMBL19365771 | 0.83 | LMNA (0.35) | ALDH1A1BTKLMNANPC1RAB9A | |
| SCHEMBL19365471 | 0.82 | ATR (0.36) | ALDH1A1LMNARAB9AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |