Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 5/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.32 |
| ▸ | PTPRB | P23467 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ACACA | Q13085 | 1/20 | 0.31 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365843 | 0.89 | RHOA (0.39) | RHOACCR3POLBRAB9ATBK1 | |
| SCHEMBL19365806 | 0.84 | RHOA (0.42) | RHOAPOLBRAB9AMCHR1GSK3B | |
| SCHEMBL19365586 | 0.80 | RHOA (0.38) | RHOAPOLBRAB9ATBK1MCHR1 | |
| SCHEMBL19365264 | 0.78 | RHOA (0.38) | RHOAPOLBRAB9AMCHR1GSK3B | |
| SCHEMBL19365867 | 0.78 | RHOA (0.37) | RHOAP2RY14CCR3GSK3BDYRK1A | |
| SCHEMBL17624583 | 0.78 | RHOA (0.37) | RHOAP2RY14CCR3GSK3BDYRK1A | |
| SCHEMBL17624672 | 0.77 | RHOA (0.35) | RHOAP2RY14CCR3GSK3BDYRK1A | |
| SCHEMBL19365833 | 0.75 | RHOA (0.43) | RHOACCR3POLBRAB9ACASR | |
| SCHEMBL19365630 | 0.75 | CTSK (0.38) | ITGB3ITGA2BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL19706079 | 0.74 | CA12 (0.40) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |