Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 3/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 6/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365654 | 0.89 | HCRTR1 (0.44) | BRD4GRM5ABL1HCRTR1 | |
| SCHEMBL19365426 | 0.87 | GSK3B (0.41) | GRM5ABL1MTOR | |
| SCHEMBL19365751 | 0.85 | GSK3B (0.38) | ABL1MTOR | |
| SCHEMBL19364893 | 0.85 | CYP1A2 (0.39) | GRM5MTORHCRTR1 | |
| SCHEMBL19365369 | 0.85 | GSK3B (0.38) | BRD4MCHR1SCDABL1MTOR | |
| SCHEMBL19865058 | 0.84 | GRM5 (0.39) | BRD4GRM5DEGS1 | |
| SCHEMBL19670246 | 0.84 | SCN9A (0.39) | MTORHCRTR1 | |
| SCHEMBL17618519 | 0.83 | SCD (0.43) | BRD4NPY5RGRM5SCDABL1 | |
| SCHEMBL19670365 | 0.83 | VCP (0.37) | GRM5ABL1HCRTR1DEGS1 | |
| SCHEMBL19670420 | 0.83 | HDAC2 (0.42) | BRD4MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |