Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 4/20 | 0.36 |
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365287 | 0.92 | VCP (0.35) | VCPF10FGFR4HCRTR2GRM5 | |
| SCHEMBL19365387 | 0.92 | VCP (0.35) | VCPF10FGFR4HCRTR2GRM5 | |
| SCHEMBL19365431 | 0.90 | IDH1 (0.34) | VCPF10FGFR4HCRTR2GSK3B | |
| SCHEMBL19365294 | 0.89 | VCP (0.35) | VCPF10GSK3BDYRK1A | |
| SCHEMBL19670153 | 0.88 | VCP (0.41) | VCPTRPV3FGFR4GRM5GSK3B | |
| SCHEMBL19670246 | 0.87 | SCN9A (0.39) | FGFR4HCRTR2HCRTR1 | |
| SCHEMBL19365745 | 0.87 | DHFR (0.38) | VCPTRPV3ABL1GSK3BDYRK1A | |
| SCHEMBL19365269 | 0.87 | KARS1 (0.45) | TRPV3ABL1GSK3BDYRK1AJAK2 | |
| SCHEMBL19670420 | 0.86 | HDAC2 (0.42) | FGFR4 | |
| SCHEMBL19364877 | 0.86 | TRPV3 (0.38) | TRPV3ABL1CNR1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |