Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 8/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365270 | 0.90 | WNT3A (0.40) | GSK3BDYRK1AABL1MTORPORCN | |
| SCHEMBL19365426 | 0.90 | GSK3B (0.41) | GSK3BDYRK1AKCNH2HRH3ABL1 | |
| SCHEMBL19364888 | 0.85 | WNT3A (0.39) | GSK3BDYRK1AMTORFAAHMAPT | |
| SCHEMBL19365284 | 0.85 | BRD4 (0.40) | ABL1MTOR | |
| SCHEMBL19365313 | 0.83 | KMT2A (0.37) | GSK3BDYRK1AFAAHMAPTKDM4E | |
| SCHEMBL16776023 | 0.83 | GSK3B (0.36) | GSK3BDYRK1AKCNH2HRH3ABL1 | |
| SCHEMBL17618518 | 0.83 | PIK3CA (0.39) | GSK3BDYRK1APIK3CAMTORFAAH | |
| SCHEMBL19365743 | 0.83 | THRB (0.40) | GSK3BDYRK1AKCNH2MTORHDAC2 | |
| SCHEMBL19365269 | 0.83 | KARS1 (0.45) | GSK3BDYRK1AABL1FAAHHDAC1 | |
| SCHEMBL19670267 | 0.82 | FGFR4 (0.41) | GSK3BDYRK1AKCNH2HRH3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |