Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670256 | 0.92 | FGFR4 (0.36) | FGFR4KCNH2CYP2C9ALOX5APHDAC1 | |
| SCHEMBL19365305 | 0.91 | ABL1 (0.36) | FGFR4KCNH2CYP2C9ALOX5APHDAC1 | |
| SCHEMBL19365311 | 0.90 | CNR2 (0.39) | FGFR4KCNH2CYP2C9ALOX5APHDAC1 | |
| SCHEMBL19365791 | 0.89 | FGFR4 (0.34) | FGFR4KCNH2CYP2C9ALOX5APHDAC1 | |
| SCHEMBL19365450 | 0.89 | HDAC1 (0.41) | FGFR4KCNH2CYP2C9ALOX5APHDAC1 | |
| SCHEMBL19365497 | 0.86 | ALOX5AP (0.40) | FGFR4KCNH2CYP2C9ALOX5APHDAC1 | |
| SCHEMBL19365705 | 0.84 | MAP4K4 (0.38) | FGFR4KCNH2CYP2C9ALOX5APHDAC1 | |
| SCHEMBL19365309 | 0.84 | CNR2 (0.40) | HDAC1MAPTGSK3BALDH1A1 | |
| SCHEMBL19670519 | 0.83 | MAP4K1 (0.41) | — | |
| SCHEMBL19706219 | 0.83 | HDAC3 (0.38) | KCNH2HDAC1MAPTGSK3BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |