Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 9/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706219 | 0.90 | HDAC3 (0.38) | GRM5MAPTGSK3BKDM4EHDAC3 | |
| SCHEMBL19364834 | 0.90 | ALDH1A1 (0.39) | ATRGSK3BALDH1A1HDAC2 | |
| SCHEMBL19670409 | 0.90 | PRMT5 (0.42) | GRM5ATRLMNAKDM4E | |
| SCHEMBL19365710 | 0.90 | CNR2 (0.52) | CNR2GRM5ATRLMNAKDM4E | |
| SCHEMBL19365441 | 0.88 | ATR (0.48) | ATRLMNAHDAC3HDAC1HDAC2 | |
| SCHEMBL19706240 | 0.88 | WNT1 (0.40) | GRM5ATRLMNAALDH1A1HDAC3 | |
| SCHEMBL19365471 | 0.88 | ATR (0.36) | GRM5ATRLMNAALDH1A1HDAC3 | |
| SCHEMBL19365583 | 0.88 | ABL1 (0.38) | GRM5ATRGSK3BALDH1A1HDAC2 | |
| SCHEMBL19670535 | 0.87 | GSK3B (0.38) | GRM5ATRMAPTGSK3BLMNA | |
| SCHEMBL19365794 | 0.87 | ATR (0.38) | CNR2GRM5ATRMAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |