Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365766 | 1.00 | ATR (0.47) | ATRNPC1RAB9ALMNATSHR | |
| SCHEMBL19365402 | 0.89 | PIK3C3 (0.42) | ATRNPC1RAB9ALMNATSHR | |
| SCHEMBL19365403 | 0.89 | PIK3C3 (0.42) | ATRNPC1RAB9ALMNATSHR | |
| SCHEMBL17618573 | 0.84 | ATR (0.45) | ATRNPC1RAB9ALMNATSHR | |
| SCHEMBL19365410 | 0.84 | RAB9A (0.41) | NPC1RAB9AGSK3BDYRK1AMEN1 | |
| SCHEMBL19365409 | 0.84 | RAB9A (0.41) | NPC1RAB9AGSK3BDYRK1AMEN1 | |
| SCHEMBL19365768 | 0.83 | EGFR (0.45) | NPC1RAB9AGSK3BDYRK1ATGFBR1 | |
| SCHEMBL19364814 | 0.83 | GRM5 (0.38) | GSK3BDYRK1AMEN1HTTKMT2A | |
| SCHEMBL19670441 | 0.83 | GRM5 (0.38) | GSK3BDYRK1AMEN1HTTKMT2A | |
| SCHEMBL19670463 | 0.83 | EGFR (0.45) | NPC1RAB9AGSK3BDYRK1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |